The DocKtor often gets asked for ideas on how to connect more than three monitors (in addition to the one native to the PC and two native to the dock).
The good news is that the DocKtor hasn't heard of too many instances lately where RF devices (wireless mice and keyboards, headsets, etc.) fail to function consistently when coupled with workstations using USB3.0 devices i.e. Targus Universal Docking Stations.
When I first started using a universal dock even I, the DocKtor, had trouble getting my head around the difference between using an old-fangled snap-in proprietary dock (sometimes called a "port replicator" - example below) and using a "universal dock".
Activity Based Working (ABW) or "Hotelling" has highlighted a Windows setting that delays the connection of USB devices while drivers are downloaded from the Microsoft Windows Update Server.
A customer found that some of their remote users were having problems logging onto internal web sites over VPN when using the Targus Universal Docking Station's GbE port.